Table of Content
- What is Calcium Alpha-Ketoglutarate (Ca-AKG)?
- How does Ca-AKG benefit skin health?
- calcium-alpha-ketoglutarate benefits
- Scientific studies on Ca-AKG and skin health
- How to incorporate Ca-AKG in skincare routine?
- Conclusion
- References
The world has recently observed the advancements in skincare segment with innovative ingredients that have the potential to combat skin ageing and improve skin health. One such next generation compound is calcium alpha-Ketoglutarate. The discovery of its benefits for skin health has sparked the interest among researchers, skincare enthusiasts, dermatologists and companies.
We are going to discuss about the science behind calcium alpha-Ketoglutarate, mode of action and how it will revolutionize skincare routine for the persons looking to improve skin texture, elasticity and overall vitality.
What is Calcium Alpha-Ketoglutarate (Ca-AKG)?
Alpha-Ketoglutarate plays an important role in Krebs cycle, a metabolic pathway that is responsible to produce energy in the cells. This compound is important for synthesis of adenosine triphosphate (ATP) that is essential for cellular function and health.
Calcium alpha-Ketoglutarate is calcium salt of AKG that provides enhanced bioavailability and stability making it easier for the body to utilize and absorb. It also provides other benefits such as supporting bone health, increasing lifespan, boosting collagen production and improving skin health.
How does Ca-AKG benefit skin health?
The skin is the largest organ and undergoes aging process with time. The factors like inflammation, oxidative stress and reduced collagen production can accelerate the skin ageing, resulting in the formation of fine lines, wrinkles and sagging. Calcium alpha-Ketoglutarate addresses these concerns by functioning at cellular level for promoting resilient and healthy skin.
Calcium Alpha Ketoglutarate benefits
1) Enhanced Collagen Production
Collagen is a protein that offers strength and elasticity to the skin. The production of collagen declines with age leading to appearance of fine lines, wrinkles and sagging skin. Calcium Alpha-Ketoglutarate plays an essential role in synthesis of collagen by supporting fibroblasts (cells responsible for collagen synthesis in dermis). It helps to maintain skin firmness, elasticity and smoothness by boosting collagen production.
2) Reduction of Oxidative Stress
The oxidative stress is a key contributor to skin ageing. The free radicals generated by environmental factors like pollution and UV radiation damages skin cell, proteins and DNA resulting in premature ageing. Calcium Alpha- Ketoglutarate exhibits antioxidant properties that neutralizes free radicals and protecting the skin from oxidative damage. Hence, It helps to prevent age spots, wrinkles, and other signs of ageing.
3) Anti-Inflammatory Properties
The chronic inflammation accelerates skin ageing by breaking down elastin fibres and collagen resulting in thinning of the skin and wrinkles formation. It exhibits anti-inflammatory properties that helps to reduce inflammation in the skin. The reduction of inflammation helps to prevent the breakdown of proteins and maintain skin integrity.
4) Support for Metabolism and Cellular Energy
The skin health is dependent on metabolism and cellular energy. Cells require energy to carry out various bodily functions such as repair, regeneration and production of elastin and collagen. Ca-AKG helps the skin cells to access required energy for the body to function. Calcium Alpha Keto- Glutarate supports faster healing of damaged skin and provide vibrant and youthful appearance.
5) Role in Skin Repair and Wound Healing
Calcium Alpha Keto –Glutarate play an important role in collagen synthesis and metabolism making it an important asset for promoting wound healing and skin repair. It also supports in improving collagen production, acne scarring and increases cell metabolism. It leads to healing leading to healthy and smooth skin.
6) Protection Against UV Damage
The UV rays’ exposure from the sun is one of the primary cause of skin ageing. The UV radiation results in free radicals that damages DBA and collagen breakdown leading to wrinkles, age spots, and loss of skin elasticity. The antioxidant properties of Calcium alpha Ketoglutarate reduces the damage caused by UV rays by neutralizing free radicals and promoting repair of damaged cells.
Scientific studies on Ca-AKG and skin health
The research on Calcium alpha Ketoglutarate for optimal skin health is in the early stages. Several studies offer insights into how AKG impact skin ageing and overall health.
- Longevity & Anti-Ageing Properties – The studies demonstrated that AKG has anti-ageing properties that helps in reducing inflammation and promoting metabolism. They suggest that AKG could have positive impact on skin ageing.
- Collagen Synthesis & Wound Healing – The studies indicate the role of Alpha Keto-Glutarate in wound healing and collagen synthesis. The researchers demonstrated that the supplementation of AKG resulted in increased collagen production and improved healing of wounds. This suggests that Ca-AKG might be an effective supplement for promoting collagen production and repairing of skin in humans.
- Antioxidant & Anti-Inflammatory Effects – The studies have highlighted that Alpha Keto-Glutarate exhibits antioxidant and anti-inflammatory properties. Ca-AKG helps to reduce the oxidative stress and inflammation that helps to combat skin ageing. The reduction of these factors results in healthy and resilient skin.
How to incorporate Ca-AKG in skincare routine?
The research exhibited that Calcium alpha-Ketoglutarate showed the improvement in skin health. Also, Ca-AKG are found in various forms like nutraceutical formulations, dietary supplements and topical formulations.
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Dietary Supplements or Nutraceutical Formulations
The companies such as nutraceutical, pharmaceutical and nutricosmetics may incorporate Calcium Alpha Keto-Glutarate in their nutraceutical formulations. It promotes collagen synthesis, supports overall cellular energy and reduces oxidative stress. It also helps to improve skin texture, hydration and elasticity.
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Topical Formulations
Topical formulations are another option for individuals looking for skin benefits. The formulations infused with Calcium Alpha Ketoglutarate anti- aging directly act on the skin for supporting collagen production, protection against oxidative damage and reduce inflammation. Incorporating Ca-AKG in topical formulations is relatively a new concept, however, show promise as an innovative ingredient for various skin concerns such as sagging, dullness and wrinkles.
Conclusion
Calcium Alpha Ketoglutarate supplement is a next generation ingredient for improving skin health and anti-ageing. It helps to enhance collagen production, combat inflammation, reduce oxidative stress, and support cellular energy, thus making it powerful tool for vibrant and youthful skin. The more research is required to understand the benefits of Ca-AKG in the skin.
As the science of skincare continues to evolve, Ca-AKG will emerge as a key ingredient in topical and dietary supplements aimed at promoting healthy and youthful skin. The incorporation of Ca-AKG into the routine may provide comprehensive support to combat visible signs of aging and maintain skin vitality.
References
- https://pubmed.ncbi.nlm.nih.gov/34817909/
- https://www.sciencedirect.com/science/article/pii/S053155652300075X
