To slow or stop the progression of osteoarthritis, conventional medicine does not yet have any proven treatment. But with the emerging solution for such bone-related disease, nutritional supplements like glucosamine and chondroitin sulfate shows proven improvement in patients suffering from osteoarthritis pain. Let’s understand these both in detail:
What is Chondroitin Sulfate?
Just like Collagen peptides, it is an important structural component of cartilage and provides much of its resistance to compressions. It is normally found in cartilage around joints in the body.
Chondroitin sulfate supplement is widely used for osteoarthritis and cataracts. It can be taken by mouth, applied to the skin, and given as a shot for many other conditions, but there is no good scientific evidence to support these uses
What are the benefits offered by Chondroitin sulfate?
Chondroitin sulfate used with conventional anti-inflammatory medications seems to help reduce hip and knee joint pain due to a type of arthritis known as osteoarthritis.
It is even effective for other conditions people use it for, including heart disease, osteoporosis (weak bones), or high cholesterol.
It is possibly effective for cataracts, Osteoarthritis, Urinary tract infections (UTIs)
What is Glucosamine?
Like chondroitin sulfate, Glucosamine is a natural chemical compound in your body helps in keeping up the health of your cartilage in. It is the rubbery tissue that cushions bones at your joints. It also comes in the form of a supplement form to help in the medical conditions you might be facing.
Source Link: www.nejm.org/doi/full/10.1056/NEJMoa052771
What are the benefits offered by Glucosamine?
Glucosamine is considered as the second most popular dietary supplement after fish oil, omega 3, or DHA, which were taken by those who took supplements. Glucosamine is possibly effective for Osteoarthritis (OA)glaucoma weight loss interstitial cystitis, a bladder condition joint pain, such as knee pain, back pain, etc.
Also, these supplements are used by people with inflammatory bowel disease (IBD) and ulcerative colitis.
Combining Glucosamine and Chondroitin Sulfate
The combination of glucosamine with chondroitin sulfate has become a widely used dietary supplement for treatment of osteoarthritis.
Many people take supplements made from glucosamine and chondroitin for OA, and especially OA of the hip or knee.
Some studies suggest that combination of glucosamine and chondroitin may have the following effects:
- Reduce osteoarthritis-related pain, stiffness, and swelling in the joints.
- Shows improvement in people with knee or hip osteoarthritis.
- Relief of symptoms for up to 3 months after someone stops treatment.
However, the Glucosamine and Chondroitin Arthritis Intervention Trial (GAIT) surveyed 1,600 participants in 16 locations across the U.S. It is found that glucosamine plus chondroitin sulfate did not give significant relief from osteoarthritis.
Some of the patients with moderate-to-severe pain reported significant relief, however, when they took the combination of glucosamine and chondroitin.
While this combination, or glucosamine alone, may relieve moderate to severe pain in people with osteoporosis, overall, it appears to be no more effective than a placebo in slowing the loss of cartilage in knee osteoarthritis.
What Science has to Says About Safety and Side Effects?
The studies show glucosamine and chondroitin sulfate to be safe and well tolerated. Common side effects may include:
- Gastrointestinal upset
These side effects are reported in a small portion of patients. However, even substances that are found naturally in the body can have unpredictable results when taken in higher than normal quantities and in different formulations. This is particularly true with patients who are taking multiple medications or who have other diagnosed illness. For example:
The previous studies suggest that glucosamine may help in increasing insulin resistance. Therefore, diabetic patients should use glucosamine with caution and only under medical supervision.
Patients on blood thinners (anticoagulants) should use chondroitin sulfate only after discussing and receiving approval from their physician.