Collagens: Game-Changing Nutraceutical Ingredients for Osteoarthritis Support

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The global prevalence of osteoarthritis, as per the report of the World Health Organization, represents a significant public health concern, with approximately 528 million individuals diagnosed in 2019—an increase of 113% from 1990. This progressive joint disease primarily impacts the knees, hips, spine, and hands, with a notably higher incidence among women. 

Osteoarthritis is a joint condition where cartilage and bone degrade over time, often due to ageing or wear and tear. The effects of osteoarthritis extend beyond physical symptoms such as pain, swelling, and stiffness, profoundly impairing mobility and reducing individuals’ capacity for daily activities and overall quality of life. Given these challenges, there is a critical need for effective symptom management and life quality enhancement for those affected by this debilitating condition.

Collagen supplements sourced from fish, chicken and bovine are crucial in osteoarthritis (OA). In healthy joints, collagen maintains cartilage structure and mechanical strength. During OA progression, enzymatic activities increase, leading to collagen degradation. This breakdown results in the loss of cartilage integrity and joint function. 

Understanding collagen dynamics in OA is vital for developing treatments to prevent collagen degradation or enhance its repair. Undenatured chicken collagen type II and collagen hydrolysates for osteoarthritis could slow the disease progression and relieve patients suffering from this debilitating condition.

Scope of The Problem

The global incidence of osteoarthritis is anticipated to increase as populations age worldwide. This condition is not limited to older individuals; younger generations, including athletes and sports professionals, are also at risk.

The impact of osteoarthritis on an individual’s life is profound. The loss of mobility and subsequent decrease in physical capabilities can severely diminish an individual’s quality of life, affecting daily activities and overall well-being. It highlights the critical need for managing symptoms and improving the overall quality of life for those suffering from this debilitating condition.

The Role of Collagens in Joint Health

Collagen, a crucial component of cartilage, plays a vital role in joint health. It acts as a cushion at the joints, absorbing shock and allowing smooth movement. However, the body’s ability to synthesise collagen diminishes with age, typically beginning to decline between 25 and 30 years. This natural process underscores the increasing importance of external collagen supplementation, regardless of age and lifestyle.

Collagen Sources and Their Efficacies

Clinically-Approved-Collagens
Clinically Approved Collagens

Collagen supplements, derived from marine, bovine, and chicken sources, offer tailored benefits for joint health. Each provides specific types of collagen crucial for cartilage repair and maintenance.

1) Marine/Fish Collagen Peptide

Sourced from fish, marine collagen is highly bioavailable, allowing for efficient absorption. It predominantly contains Type I collagen, which benefits the skin and contributes to the health of bones and joints.

Marine or fish collagen is increasingly recognised for its role in supporting joint and bone health, primarily due to its high levels of Type I collagen, the most abundant collagen in the human body. This type of collagen is essential for maintaining the structural integrity of bones. It is a significant component of the articular cartilage found in joints, facilitating smooth movement and reducing friction. 

The high bioavailability of fish collagen means that it is efficiently absorbed into the bloodstream, where the body can effectively use it to repair and rebuild bone and cartilage tissues. Moreover, the amino acids in fish collagen, such as glycine and proline, contribute to the regeneration of joint cartilage and can help reduce inflammation within the joints, thereby alleviating pain and improving mobility in individuals with joint degeneration or osteoarthritis. 

Thus, fish collagen supplements enhance the health and functionality of joints and bones. The dosage for osteoarthritis is 10g of fish collagen.

2) Bovine Collagen

Extracted from Bovine Sources, bovine collagen is rich in Types I and III collagen. These types support the structural integrity of skin, bones, muscles, and cartilage, making bovine collagen particularly useful for osteoarthritis management.

Bovine collagen plays a pivotal role in the health and functionality of joints and bones, primarily due to its rich content of Types I and III collagen. These specific types are integral to cartilage’s structural integrity and repair, essential for smooth and pain-free joint movement. 

Type I collagen, in particular, is also crucial for bone health as it maintains bone density and strength. Bovine collagen provides a spectrum of amino acids like glycine and proline, which are vital for synthesising and repairing connective tissue throughout the body, including joints and bones. Bovine collagen, a collagen supplement, can help mitigate the symptoms of degenerative conditions like osteoarthritis and contribute to overall joint and bone health, making it an essential supplement for maintaining mobility and structural integrity. The bovine collagen dosage for osteoarthritis is 10g.

3) Chicken Collagen

Chicken collagen is a source of Type II collagen, the predominant form of collagen found in cartilage, the connective tissue that cushions joints. This collagen type is crucial for maintaining the strength and flexibility of joints and bones. By directly supplementing with chicken collagen, the best collagen for knee osteoarthritis, individuals may help replenish and preserve the structural integrity of cartilage, thus reducing the wear & tear leading to osteoarthritis. 

Additionally, Type II collagen has been shown to play a role in the body’s immune response, potentially helping to minimise inflammation that often exacerbates joint pain and degradation. Regular supplementation with chicken collagen can effectively support joint health and maintain bone strength, enhancing mobility and quality of life. The undenatured chicken collagen type-II dosage for osteoarthritis is 40 mg. 

Undenatured Type II Collagen: A Focused Approach

Undenatured Type II collagen is particularly effective for managing osteoarthritis due to its unique mechanism of action among the different collagen forms. It retains its native triple-helix structure and has been shown to modulate the immune system’s response to exposed cartilage proteins. This modulation can decrease inflammation and prevent further cartilage degradation, contributing to joint comfort and mobility. It is one of the best Type II collagen for osteoarthritis. 

Prevention Is Better Than Cure

The increasing global incidence of osteoarthritis calls for effective and accessible management strategies. Collagen supplementation, through its various sources—marine, bovine, and chicken— provides a versatile and potent approach to supporting joint health and enhancing the quality of life for osteoarthritis patients. The supplements offer specific types of collagen essential for repairing and maintaining cartilage, the tissue that cushions joints. 

As natural collagen production declines with age, supplementation can help replenish collagen levels, supporting cartilage integrity and function. Each source offers unique benefits: Marine/fish collagen is highly bioavailable. Bovine collagen is rich in types I and III collagen. Chicken collagen is particularly beneficial for joint cartilage. Hence, collagen peptides and Undenatured chicken collagen type –-II for knee osteoarthritis are essential for the repair and maintenance of cartilage and can help mitigate the symptoms and progression of osteoarthritis. 

About Titan Biotech Limited

Titan Biotech Limited is the leading and trusted manufacturer and exporter of premium quality raw material ingredients for various sectors, such as nutraceuticals, pharmaceutical, cosmeceuticals, and food and beverage. We are a BSE-listed organisation. 

Established in 1992, we have diversified into multiple segments over the past 32 years. We have 5 state-of-the-art manufacturing units in Bhiwadi, Rajasthan and a market presence in 100+ countries.

We are a leading manufacturer of clinically approved and tested Collagen (Fish, Bovine, and Chicken), Skin care ingredients (Hyaluronic Acid, Glutathione, Coenzyme Q10), Bone and joint care ingredients (Chondroitin Sulfate, Mucopolysaccharides, Glucosamine, MSM), proteins, and many more. The company has several internationally recognised certifications: ISO 9001: 2015, ISO 13485:2016, FSSAI, FSSC 22000, HALAL India, and GMP.

Hence, if you require clinically approved collagens for incorporation into your bone & joint care formulations, you may contact us by mail or phone. Our technical experts will provide customised solutions at reasonable rates. 

References
  • https://www.who.int/news-room/fact-sheets/detail/osteoarthritis
  • https://www.sciencedirect.com/science/article/abs/pii/S1568163723002398
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057461/
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8620403/
  • https://josr-online.biomedcentral.com/articles/10.1186/s13018-023-04182-w
  • https://link.springer.com/article/10.1007/s40744-020-00240-5
  • https://www.sciencedirect.com/science/article/pii/S2405844023021680