Undenatured Chicken Collagen Type II: Mode of Action and Benefits

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Collagen has experienced a surge in popularity in the market, emerging as a sought-after ingredient in various health and beauty products. It is known for promoting joint health, skin elasticity, and overall well-being. Collagen supplements especially Undenatured Chicken Collagen Type 2 have gained importance among individuals looking to enhance their physical appearance and support their body’s structural integrity. 

From collagen-infused skincare products promising youthful skin to dietary supplements aiming to improve joint flexibility, the market has witnessed a plethora of innovations capitalizing on collagen’s widespread appeal. This surge in demand can be attributed to the growing awareness of the protein’s benefits, coupled with a cultural shift towards prioritizing holistic approaches to health and beauty. As collagen continues to gain traction, its versatility and positive associations with overall wellness are likely to keep it at the forefront of consumer preferences in the foreseeable future.

Applications of Collagens Across Industries 

Collagen has become a versatile and indispensable ingredient in various sectors, particularly in promoting bone and joint health. In the nutraceutical industry, collagen supplements are widely utilized to support joint function and alleviate conditions like osteoarthritis, owing to collagen’s role in maintaining cartilage integrity. 

The food and beverage sector has also embraced collagen, with collagen-infused products ranging from protein bars to beverages, offering consumers a convenient way to incorporate this beneficial protein into their daily diet. The cross-industry applications of collagen underscore its multifaceted contributions to health and well-being, making it a key player in the quest for holistic approaches to maintaining bone and joint health.

Increasing Prevalence of Bone & Joint Issues

The joint care market has witnessed significant growth in response to the escalating prevalence of joint and bone problems across all age groups. The joint-related issues such as osteoarthritis and rheumatoid arthritis have become more prevalent in an aging population, driving the demand for effective and innovative solutions. 

Moreover, an increasingly sedentary lifestyle and the rise in musculoskeletal conditions among younger individuals have further fuelled the expansion of the joint care market. The market’s dynamism is evident in the diverse range of products, including supplements, pharmaceuticals, and nutraceuticals, all designed to address joint discomfort, improve flexibility, and promote overall musculoskeletal health. 

As awareness about preventive healthcare rises, consumers are proactively seeking products that offer joint support, leading to a continual surge in the joint care market. This trend underscores the pressing need for comprehensive strategies to address joint and bone issues across various age demographics, making the joint care market a focal point in the broader landscape of health and wellness.

What is Undenatured Chicken Collagen Type 2: A Perfect Collagen for Bones & Joints

Undenatured chicken collagen type 2 is a specific form of collagen renowned for its potential benefits in promoting joint health. It is derived from the sternum of chickens, and the collagen type retains its natural and undenatured state, preserving its molecular structure intact. 

As we age, collagen production naturally decreases, leading to weak bones and problems in moving joints freely. Collagen is a key component of cartilage, offering cushioning and promoting joint flexibility. It is particularly significant in preventing conditions like arthritis and ensuring overall mobility.

What sets Undenatured chicken collagen type 2 apart is its high concentration of Undenatured type 2 collagen proteins, including Chondroitin Sulfate and Hyaluronic Acid. These components are crucial for supporting cartilage and joint function. Undenatured collagen type 2 is often sought after for its potential to modulate the immune system and promote a healthy inflammatory response, making it a popular choice for those dealing with joint discomfort or conditions like osteoarthritis. 

Undenatured chicken collagen type 2 uses comprises of enhancing joint flexibility, reduce inflammation, and supports overall joint wellness, providing individuals with a natural and holistic approach to maintaining joint health.

Oral Tolerance: A Unique Mechanism of Action

The process of oral tolerance presents a distinctive mechanism of action for native type II collagen when taken orally. As it passes through the stomach, Undenatured collagen remains intact, bypassing denaturation and reaching the small intestine unaltered. The key to this unique mechanism lies in the preservation of intact epitopes on Undenatured collagen, facilitating the process of oral tolerance.

Upon reaching the small intestine, the Undenatured collagen molecule engages with the immune system within Peyer’s patches (discrete lymphoid nodules scattered throughout the ileum of the small intestine). These patches play a central role in the mucosal immune system, surveilling the small intestine and signaling immune responses to foreign antigens. 

In the Peyer’s patch environment, ingested native type II collagen is recognized as such, binding to specific immune cells. This binding triggers a signal that communicates to the immune system, prompting it to cease its attack on the body’s own type II collagen within joint cartilage.

It is crucial to emphasize that native type II collagen does not get absorbed by the body. Instead, it performs its immunomodulatory function within the intestinal lumen by binding to immune cells before being excreted from the body. This unique mechanism allows for the effectiveness of native type II collagen in reducing inflammation and protecting against collagen degradation. 

In contrast to standard dosages for hydrolyzed collagen, which may require up to 10 grams daily, the standard dose for native (undenatured) collagen is a mere 40 mg once daily, underscoring the potency and efficiency of this specific approach to oral tolerance.

Clinical Studies Supporting Undenatured Chicken Collagen Type II Benefits

Clinical Studies Supporting Undenatured Chicken Collagen II Benefits

The clinical study and research have supported the benefits of Chicken collagen II that are discussed below:

  • Reduction in Joint Discomfort

As per studies, undenatured type II collagen is effective in reducing joint discomfort associated with osteoarthritis. It was proposed that undenatured collagen could modulate the immune response and promote joint health.

  • Improvement in Joint Function

Research published in The Eurasian Journal of Medicine indicated that undenatured type II collagen might contribute to improvements in joint function and overall quality of life for individuals with osteoarthritis.

  • Immunomodulatory Effects

Undenatured collagen type II powder has been investigated for its immunomodulatory effects, potentially preventing the immune system from attacking joint tissues. This process may prevent the immune system from attacking the body’s collagen, particularly relevant in conditions where autoimmune responses affect joint tissues such as rheumatoid arthritis. 

  • Cartilage Protection

By promoting the synthesis of new collagen and proteoglycans, undenatured collagen may help protect and regenerate cartilage, the tissue that cushions and protects the ends of bones within joints.

  • Reduced Inflammation

Some studies suggest that undenatured chicken collagen type 2 may have anti-inflammatory effects, contributing to a reduction in inflammation within the joints.

  • Lower Dosage Requirement

Unlike some other collagen supplements, undenatured chicken collagen often requires lower daily dosages (e.g., 40 mg once daily), making it a more efficient option for those seeking joint support.

Undenatured Chicken Collagen vs Hydrolyzed Collagen

The primary difference between Undenatured chicken collagen type II and hydrolyzed chicken collagen lies in their processing methods and, consequently, their molecular structures and potential applications.

ParameterUndenatured Chicken Collagen Type IIHydrolyzed Chicken Collagen
ProcessingUndenatured collagen type II is obtained through a minimal processing method that preserves the natural structure of the collagen molecules. It is typically sourced from the sternum of chicken.Hydrolyzed collagen undergoes a process called hydrolysis, where collagen molecules are broken down into smaller peptides through enzymatic or chemical treatment. This process results in collagen peptides that are more easily absorbed by the body.
Molecular StructureIt retains its native and undenatured form, including key components like chondroitin sulfate and hyaluronic acid. It is essential for maintaining the collagen's biological activity.The hydrolyzed collagen is smaller and may lose the native structure found in undenatured collagen. It makes them more bioavailable for digestion and absorption.
ApplicationUndenatured chicken collagen type II is often associated with joint health and immune system modulation. It is commonly used as a supplement to support joint function and alleviate conditions like osteoarthritis.Hydrolysed chicken collagen is often used in a variety of products, such as dietary supplements, skincare, and functional foods. The versatility lies in its ease of incorporation into various formulations due to its smaller particle size and enhanced solubility.

While both undenatured chicken collagen type II and hydrolyzed chicken collagen offer potential health benefits, undenatured collagen type II is particularly emphasized for joint health, maintaining its natural structure, while hydrolyzed collagen is favored for its versatility in various applications due to its smaller, more easily absorbed peptides.

Reasons to Select Undenatured Chicken Collagen Type II

Reasons to Select Undenatured Chicken Collagen II

Choosing undenatured chicken collagen type II is a strategic decision based on several factors that distinguish it from other collagen supplements. Here are some reasons why companies might opt for undenatured chicken collagen.

  • Joint Health Benefits- Undenatured chicken collagen type II is specifically associated with joint health. Its unique composition, including intact epitopes, may contribute to the maintenance of joint function and the alleviation of joint discomfort.
  • Oral Tolerance Mechanism- The process of oral tolerance, where undenatured collagen interacts with the immune system in the small intestine, is a distinctive feature. This mechanism may help modulate the immune response and prevent the body from attacking its collagen, making it particularly relevant for conditions involving autoimmune responses affecting joint tissues.
  • Preservation of Natural Structure- Undenatured collagen retains its natural structure, including essential epitopes, which are important for its biological activity. Preserving this structure is believed to enhance collagen’s effectiveness in supporting joint health.
  • Reduced Dosage Requirement- Undenatured chicken collagen often requires lower daily dosages compared to some other collagen supplements. For instance, the standard dose for native (Undenatured) collagen is often as low as 40 mg once daily, making it a more efficient option for those seeking joint support.
  • Focus on Specific Health Concerns- Individuals looking for targeted support for joint-related issues, such as osteoarthritis or joint discomfort, may choose Undenatured chicken collagen due to its association with joint health and potential immune system modulation.
  • Holistic Approach to Joint Care- Undenatured chicken collagen offers a holistic approach to joint care by addressing not only the physical aspects of joint health but also considering the immunomodulatory effects that may play a role in preventing or reducing inflammation within the joints.
About Titan Biotech Limited

Titan Biotech Ltd., based in Delhi, India, specializes in supplying premium-grade raw material ingredients to different industries, including pharmaceuticals, nutraceuticals, cosmeceuticals, and the Food and Beverage sector. Our company is a leading manufacturer and exporter of Undenatured Chicken Collagen Type II (Unstergen®), Fish Collagen (Titagen®), Bovine Collagen ( Titabon™),  Ox Bile Extract (Oxibil™), Bone and Joint and Skin-care Ingredients, Food Ingredients, Yeast Extract, and more for many critical applications.

Our strong presence in the market allows us to stay abreast of local trends, enabling us to collaborate with key players in the industry worldwide. We have 5 state-of-the-art manufacturing facilities in Bhiwadi, Rajasthan. Our commitment to excellence is reflected in the production process, which adheres to international quality standards such as ISO and GMP.

Hence, if you are looking for Unstergen® (Undenatured Chicken Collagen Type 2) or any other ingredient then you can contact us. Our marketing representative will provide customized solutions as per your requirements. 


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